North Carolina is bordered by South Carolina on the south, Georgia on the southwest, Tennessee on the west, Virginia on the north, and the Atlantic Ocean on the east. The United States Census Bureau places North Carolina in the South Atlantic division of the southern region.

North Carolina consists of three main geographic regions: the Atlantic coastal plain, occupying the eastern portion of the state; the central Piedmont region, and the mountain region in the west, which is part of the Appalachian Mountains. The coastal plain consists of more specifically-defined areas known as the Outer Banks, a string of sandy, narrow barrier islands separated from the mainland by sounds or inlets, including Albemarle Sound and Pamlico Sound, the native home of the venus flytrap, and the inner coastal plain, where longleaf pine trees are native.